R&D > Equipment

F.I.S. R&D teams expertise in organic synthesis and analytical methodology, coupled with the amount and variety of available analytical instruments, makes F.I.S. the ideal partner for process development and validation.

Together with the conventional equipment for the organics synthesis, F.I.S. R&D has got dedicated front-end technologies for analytical research and development operations including expertise for Potential Genotox Impurities assessment and determination.

  • 50 HPLC
  • 15 Fast-HPLC/UPLC
  • 20 GC
  • 13 GC-HS
  • 2 GC-MS
  • 3 Prep. HPLC for impurities isolation and carry over studies
  • 2 NMR 400 MHz (1H, 13C, 19F, 31P, 15N), one is equiped with Nanoprobe for solid state investigation
  • Infrared spectroscopy
  • Ultraviolet spectroscopy
  • Polarimetry
  • Mass spectroscopy, 2 GCMS; 2 LCMS-IT, 1 LCMS(Q), 1 LCGCMS(3Q) 1 LCMS(QTOF)
  • Particle size determination (3 Laser systems; Alpine system)
  • Thermal analysis
  • Surface area determination
  • Capillary zone electrophoresis
  • Climatic Rooms for stability studies
  • ICP MS
  • ICP-OES
  • Atomic absorption spectroscopy
  • XRPD (Bruker D8 Advance diffractometer)

Process Hazard Laboratory

  • RC-1 Reaction Calorimeter (T: -70/+150°C)
  • RC-1 Reaction Calorimeter (T: -40/+230°C)
  • C-80 Calvet Reaction Calorimeter
  • PHITEC II Adiabatic Calorimeter
  • DSC-Differential Scanning Calorimeter
  • TGA – Thermo gravimetric analysis

Solid State Characterization Laboratory

  • Lasentec FBRM probe – In-line particle size distribution analysis
  • Lasentec PVM probe – In-line particle microscopy

Process Analytical Technlogies

  • FT-IR Probe
  • Lasentec FBRM probe – In-line particle size distribution analysis
  • Lasentec PVM probe – In-line particle microscopy
  • RAMAN
  • Mass Analys